EVALUATION OF GONADAL FUNCTION IN YOUNG MEN AND WOMEN DIAGNOSED WITH HODGKIN LYMPHOMA

Background: ABVD or escBEACOPP chemotherapy (CT) ± radiation is the treatment approach for Hodgkin lymphoma (HL) patients. As a result of improvement, long-term survivors and treatment-related complications are recognized, among which, gonadal insufficiency plays cenrtal role. Moreover, little known about kinetics function sex hormones during CT to guide contraceptive measures. Subjects Methods: This prospective study in HL patients, with an age limit ≤40 years women ≤45 men. We present our results on 94 Measurements were performed at pre-specified time points: before (t0), CT(t1), end CT(t2) every six months (t6, t12) thereafter. The following measured: follicle-stimulating hormone (FSH), lutenizing (LH), progesterone (PG), estradiol (Ε2), anti-Mullerian (ΑΜΗ) FSH, LH, AMH, testosterone Results: included 55 men (median 30 years) 39 29 HL, all first-line ABVD. In men, FSH increased from start treatment, peaked remained high 6 after CT: [t0 = 3.8 IU/mL, t1 11.07 t2 15 t6 7.4 fsh0–1 p < 0.001, fsh0–2 0,001, t0–6 0.001], while it normalized 12 months. AMH progressively beginning up (t0 8, 05 ng/mL, 8.40 13.21 ng, 13, 52 t12 13.04 ng/mL amh0–1 0.002, amh0–2 amh0–6 amh0–12 0,05). Testosterone treatment: 407 ng/dL, 523 535 ng/dl, t0–1 t0–2 0,001), returned normal levels CT. women, showed increase CT, middle end: 4.1 U/mL, 8.8 7.7 6.6 0.01, fsh0–6 0.05). decrease its low until 2.85 0.45 0.62 0.001), later. Sex unaffected. Keywords: lymphoma, late effects survivors, other No conflicts interests pertinent abstract.